In recent years, hyperscale data centers have been optimized for scale-out stateless applications and zettabyte storage, with a focus on CPU-centric platforms. However, as the infrastructure shifts towards next-generation AI applications, the center of gravity is moving towards GPU/accelerators. This transition from "millions of small stateless applications" to "large AI applications running across clusters of GPUs" is pushing the limits of accelerators, network, memory, topologies, rack power, and other components.